MERGERS, ACQUISITIONS & ASSET SALES |
Acquiring Company |
Target(s) |
Deal Summary |
Roche |
Flatiron Health |
- Price: $1.9 billion
- Status: Closed
- Roche already held 13% stake in Flatiron
- Acquisition of Flatiron’s oncology technology assets boosts Roche’s personalized healthcare infrastructure
|
Agilent |
Lasergen |
- Price: $105 million
- Status: Agreement exercising option to acquire remaining shares of NGS tech firm with no closing date announced
- In 2016, Agilent acquired a 48% equity stake in company
- Plan is to combine Agilent’s engineering expertise with Lasergen’s sequencing chemistry to build entire clinical sequencing workflow
- Newly merged firm to be called LaserGen
|
Prenetics |
DNAFit |
- Price: $10 million
- Status: Closed
- Acquisition of UK-based wellness genetics company represents entry of Prenetics, known for pharamacogenomics and reproductive testing, into consumer genomics market
|
Aurora Diagnostics |
Cascade Pathology Services |
- Price: Undisclosed
- Status: Closed
- In addition to Oregon physician-owned multispecialty pathology practice, Aurora acquires Cascade Cytology Reference Laboratories, an affiliated lab providing cytology support services to physician groups
- Aurora now owns 32 physician practices
|
BioMérieux |
Astute Medical |
- Price: $90 million in cash
- Status: Closed
- Astute produces tests for identifying and validating protein biomarkers of medical conditions, including Nephrocheck, an FDA cleared test assessing risk of kidney injuries
|
UCB |
Element Genomics |
- Price: $30 million, including upfront and short-term success-based milestone payments
- Status: No closing date announced
- Acquisition of Duke Univ. biotech spinout bolster UCB’s biopharm development pipeline
- Element to remain based in Durham, NC, while working with UCB international research teams
|
Thompson Street Capital Partners (private equity firm) |
Transnetyx |
- Price: Undisclosed
- Status: No closing date announced
- Thompson Street to acquire YX Genomics Holding, the holding company of Transnetyx, lab management services firm YX Services, and robotics company RobotYX
|
Apax Partners |
Minority stake in Vyaire Medical held by Becton Dickinson |
- Price: $435 million in cash
- Status: Expected to close by end of April
- BD to use proceeds in line with its broader capital allocation strategy and says that divestiture will not no material impact on FY 2018 revenue or adjusted earnings
|
Mars Petcare |
OptiGen |
- Price: Undisclosed
- Status: Closed
- Mars acquires DNA diagnostics company specializing in canine inherited disorders, exclusive licenses to genetic disease tests and biobank of over 150,000 samples
|
STRATEGIC ALLIANCES, PARTNERSHIPS & COLLABORATIONS |
Partner 1 |
Partner 2 |
Deal Summary |
Quest Diagnostics |
Humana
+
Multiplan
+
United Health Group’s Optum
+
UnitedHealthcare |
- Objective: Create national alliance to use blockchain technology to improve quality data and cut administrative costs
- Dynamic: Launch of pilot program evaluating how sharing data across healthcare organization on blockchain technology can improve data accuracy, streamline administration and improve access to care
|
Mologic |
PATH |
- Objective: Develop rapid diagnostic test (RDT) to support treating and eliminating Plasmodium vivax malaria
- Dynamic: International nonprofit PATH to support Mologic in commercializing and getting regulatory approvals for RDT
|
Illumina |
Bristol-Myers Squibb |
- Objective: Develop companion DX tests for BMS’ cancer drug pipeline
- Dynamic: Create diagnostic version of Illumina’s TruSight Oncology 500 biomarker assay to run on Illumina’s NextSeq 550Dx platform
|
Illumina |
Loxo Oncology |
- Objective: Develop sequencing-based pan-cancer companion diagnostics for two of Loxo’s targeted oncology drugs
- Dynamic: Companies to use Illumina’s TruSight 170 panel to create test for Illumina’s NextSeq 550Dx platform
- Plan is to validate NTRK fusions and RET fusions/mutations assays as Class III FDA-approved diagnostic in conjunction with Loxo’s larotrectinib and LOXO-292, respectively
|
Thermo Fisher Scientific |
Biocept |
- Objective: Form broad commercial collaboration
- Dynamic: As first step, Biocept’s lab to validate Thermo Fisher’s Oncomine NGS liquid biopsy panels
- Thermo Fisher intends to designate Biocept as a Center of Excellence clearing way for oncology liquid biopsy initiatives
|
Agilent Technologies |
BioTek Instruments |
- Objective: Develop integrated product for cellular metabolic analysis and imaging
- Dynamic: Integrate Agilent’s Seahorse XFe96/XFe24 Analyzers with BioTek’s Cytation 1 Cell Imaging Multi-Mode Reader
|
RTI International |
PierianDx |
- Objective: Promote PierianDx’s genomics platform
- Dynamic: RTI also to make undisclosed investment and provide other strategic support to advance PierianDx’s growth plan
|
DiaCarta |
MIODx |
- Objective: Develop test to predict immunotherapy response based on MIODx’s ClonoMap immune sequencing technology
- Dynamic: Test to be developed and validated at DiaCarta’s San Francisco Bay Area and Nanjing, China labs
|
PerkinElmer |
Heli
+
NorthShore University Health System |
- Objective: Develop two new DX applications for Helix’s online genomics marketplace
- Dynamic: PerkinElmer to develop and launch first app used to report pathogenic variants in 59 genes linked to serious diseases on marketplace
- NorthShore to apply its genetic risk scoring tech to create method of assigning polygenic prostate cancer risk score on marketplace
|
PerkinElmer |
Biotechnology Industry Research Assistance Council |
- Objective: Promote India-led biomed, biotech and public health startups
- Dynamic: Parties sign letter of intent agreeing to work together for five years
|
UgenTec |
Serosep |
- Objective: Add Serosep’s EntericBio assays to UgenTec’s FastFinder platform
- Dynamic: Partnership similar to UgenTec’s existing arrangements with MDxHealth, Fast Track Diagnostics and SpeeDx
|
UgenTec |
Hamilton Robotics |
- Objective: Remedy lab automation issues in molecular diagnostics industry
- Dynamic: Launch of New Molecular Automation Network, consortium to promote partnerships facilitating exchange of business and technical info between labs and manufacturers of automated liquid handling workstations, real-time PCR devices and software
- UgenTec and Hamilton Robotics to exchange technical expertise and integrate their software and hardware systems
|
IncellDx |
CellMax Life |
- Objective: Develop and market circulating tumor cell tests
- Dynamic: CellMax to combine its CTC isolation technology with IncellDx’s BioINK microfluidic reagents
- Tests to be processed at CellMax’s California lab and jointly marketed in US by CellMax’s sales force
|
ArcherDX |
Washington University in St. Louis |
- Objective: Study minimum residual disease in pediatric acute myeloid leukemia patients
- Dynamic: Researchers to use ArcherDX’s sequencing technology to analyze patients in clinical trial analyzing different treatments of pediatric AML patients with Down syndrome
|
ArcherDX |
Ambry Genetics |
- Objective: Provide immune repertoire sequencing services to biopharms
- Dynamic: Ambry to use ArcherDX’s Immunoverse and VariantPlex NGS assays for immune repertoire sequencing and chimeric antigen T cell receptor manufacturing characterization
|
Protagen |
Gustave Roussy Institute of Oncology |
- Objective: Identify biomarkers for immune system-related side effects in cancer patients treated with checkpoint inhibitors
- Dynamic: Protagen’s SeroTag platform for simultaneously measuring autoantibody levels for different antigens to be used to test cancer immunotherapy patients for markers linked to immune-related adverse events
- Ultimate goal is to develop risk-profiling test for immunotherapy patients
|
PathoQuest |
Charles River Laboratories |
- Objective: Expand previously announced partnership for delivery of NGS services to biologics industry
- Dynamic: Charles River to directly invest unspecified amount in PathoQuest
|
Personal Genome Diagnostics |
Five Prime Therapeutics |
- Objective: Develop blood-based companion DX assay for use with Five Prime’s investigational drug candidate, bemarituzumab
- Dynamic: PGDx to create and validate circulating tumor DNA test to identify patients eligible for treatment with drug
- Five Prime to use to select patients for Phase 3 of its registrational FIGHT trial evaluating bemarituzumab in combination with chemotherapy as front-line treatment in patients with advanced gastric or gastroesophageal junction cancer with FGFR2 amplification
|
3D Signatures |
MDxHealth |
- Objective: Evaluate 3DS’s Telo-PC test for prostate cancer for use on TeloView software platform
- Dynamic: Companies to share study costs
- 3DS to also grant MDxHealth an exclusive licensing option for Telo-PC test
|
Agena Bioscience |
Simcere Diagnostics (subsidiary of Simcere Pharmaceutical) |
- Objective: Develop and market companion DX and pharmacogenomic tests in China
- Dynamic: Simcere to develop panels based on Agena’s MassArray mass spectrometry-based genetic analysis system for Chinese market with Agena to provide commercial support
|
Biodesix |
Checkmate Pharmaceuticals |
- Objective: Biomarker research studying circulating proteome of patients with advanced melanoma treated with CMP-001 in combination with pembrolizumab
- Dynamic: Researchers to use Biodesix’s Diagnostic Cortex AI-based biomarker discovery platform
|
Laboratory Corporation of America |
Appalachian Regional Healthcare |
- Objective: Form multiyear lab partnership
- Dynamic: LabCorp Diagnostics to provide technical services for the health system’s hospital-based labs and reference testing for its entire network
- Appalachian to also gain access to LabCorp Diagnostics’ info technology and data analytics services to improve patient care
|
GenePOC |
Primerdesign (molecular testing division of Novacyt) |
- Objective: Develop molecular influenza and respiratory virus assay
- Dynamic: Primerdesign to develop test for influenza A, influenza B and respiratory syncytial virus to be run on GenePOC’s Revogene instrument
- GenePOC will to seek CE-IVD marking and FDA clearance for test
|
DISTRIBUTION, SALES & MARKETING AGREEMENTS |
Property Owner |
Distributor |
Deal Summary |
Twist Bioscience |
Recenttec KK |
- Products: Twist’s synthetic DNA and NGS products including new exome and custom target enrichment product
- Territory: Japan
|
Twist Bioscience |
LnCBio (subsidiary of DNA Link) |
- Products: Twist’s synthetic DNA and NGS products including new exome and custom target enrichment product
- Territory: Korea
|
Twist Bioscience |
Premas Life Sciences |
- Products: Twist’s synthetic DNA and NGS products including new exome and custom target enrichment product
- Territory: India
|
Twist Bioscience |
BioArrow Technology |
- Products: Twist’s synthetic DNA and NGS products including new exome and custom target enrichment product
- Territories: Hong Kong and Macau
|
Rellergen Biotech |
ALK |
- Product: Rellergen Biotech’s Bio-IC allergy diagnostic technology
- Territory: China
|
Ortho Clinical Diagnostics |
Thermo Fisher Scientific |
- Products: 14 assays for monitoring therapeutics, immunosuppressants and drugs of abuse for use on Ortho’s Vitros 4600 chemistry system and Vitros 5600 integrated system
- Territories: North America, Europe, Africa, and Middle East
|
Interpace Diagnostics Group |
Acupath Laboratories |
- Products: Interpace’s ThyGenX and ThyraMIR tests
- Territories: Undisclosed
|
OncoDNA |
PromTest |
- Products: OncoDNA’s tumor profiling products
- Territory: Armenia
|
Streck |
Van Xuan Medical Technology |
- Products: Streck’s cell stabilization and molecular products
- Territory: Vietnam
- Three-year distribution agreement
|
Genedrive |
Arkray Healthcare |
- Products: Genedrive HCV ID kit and platform
- Territory: India
- Genedrive responsible for product development, quality management and manufacturing; Arkray responsible for sales, marketing, customer support and distribution in India
|
Akers Biosciences |
Diagnostica Stago |
- Product: Akers Biosciences’ PIFA PLUSS RF4 Rapid Assay for heparin-induced thrombocytopenia
- Territory: US
- Three-year distribution agreement
|
LICENSES |
Licensor |
Licensee |
Deal Summary |
SUNY Upstate Medical |
Quadrant Biosciences |
- Property: Undisclosed epigenetic biomarker technology for autism spectrum disorder
- Expansion of existing collaboration
|
Penn State University |
Quadrant Biosciences |
- Property: Undisclosed epigenetic biomarker technology for concussion and Parkinson’s disease
- Expansion of existing collaboration
|
System Biosciences |
Qiagen |
- Property: SBI’s ExoQuick exosome isolation technology for research use
- Worldwide, non-exclusive
- Qiagen to use technology in its precipitation-based miRcury Exosome Kits, complementing its spin column-based exoEasy and exoRNeasy products
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SUPPLY, SERVICE & TESTING AGREEMENTS |
Supplier/Servicer |
Client/User |
Deal Summary |
Owlstone Medical |
AstraZeneca |
- AstraZeneca gets access to Owlstone’s Breath Biopsy Services to help in identifying breath-based biomarkers and classification algorithms for COPD with aim of identifying disease phenotypes and the best treatments
|
Theradiag |
Biogaran |
- Theradiag to supply its Lisa Tracker monitoring kits for use in monitoring responses to biosimilar drugs sold by Biogaran
|