MERGERS, ACQUISITIONS & ASSET SALES |
Acquiring Company |
Target(s) |
Deal Summary |
Illumina |
Pacific Biosciences |
- Price: $1.2 billion cash ($8 per share, representing 71% premium over market for 30 days ending Oct. 31)
- Status: Agreement approved by boards of both companies to close in mid-2019
- PacBio long-read sequencing technology complements Illumina short-read sequencing platforms and enables it to provide integrated workflows and innovations that leverage both technologies
|
Quest Diagnostics |
Oxford Immunotec Global |
- Price: $170 million cash
- Status: Closed
- Acquisition of Oxford Immunotec’s US lab business including T-Spot.TB tuberculosis and Accutix tick-borne disease testing services
- Oxford Immunotec to sell T-SPOT.TB test kits and accessories to Quest but keep T-SPOT.CMV and C6 Lyme ELISA assay kit
- Sides to enter strategic agreement to grow T-Spot.TB testing in US
|
Quest Diagnostics |
Marin General Hospital |
- Price: Undisclosed
- Status: To close by end of 2018
- Quest acquires non-profit hospital’s outreach lab services operations
|
BioMérieux |
Suzhou Hybiome Biomedical Engineering |
- Price: Undisclosed
- Status: Closed
- BioMérieux acquires 54% of Chinese immunoassay firm after acquiring minority stake in July
|
NeoGenomics |
Genoptix |
- Price: $125 million cash + 1 million shares NeoGenomics stock
- Status: Definitive agreement with no closing date announced
- Acquisition of clinical oncology lab boosts NeoGenomics’ heretofore limited ties to community oncology practices
|
Chembio Diagnostics |
OpTricon |
- Price: $5.5 million cash
- Status: Expected to close in 2018
- Since 2015, companies have collaborated to develop DPP Micro Reader, handheld, battery operated analyzer that uses an image sensor to quantitatively interpret diagnostic results when combined with Chembio’s DPP tests
|
Bruker |
Hain Lifescience |
- Price: Undisclosed
- Status: Closed
- Bruker acquires 80% stake in German molecular diagnostics firm with option to acquire remaining 20%
|
Progentec Diagnostics |
LupusCorner |
- Price: Undisclosed
- Status: Closed
- Progentec acquires health management platform for systemic lupus erythematosus and lupus nephritis patients
|
Medicover |
Invitro |
- Price: $6.9 million cash
- Status: Expected to close in 2018
- Poland-based Medicover to acquire Invitro’s Ukrainian lab operations with both businesses to be consolidated in 2019
|
STRATEGIC ALLIANCES, PARTNERSHIPS & COLLABORATIONS |
Partner 1 |
Partner 2 |
Deal Summary |
IntegraGen |
Google Cloud |
- Objective: Promote use of personalized medical care by facilitating genomics research projects and analysis of sequencing data
- Dynamic: Integrate IntegraGen’s Sirius and Mercury genomic analysis tools into Google Cloud Platform
|
Illumina |
Blue Cross Blue Shield Association |
- Objective: Enhance understanding of the state of precision medicine in US
- Dynamic: By early 2019, create report on availability and clinical understanding of DNA sequencing technologies, genetic testing and precision medicine
|
Sophia Genetics |
Paragon Genomics |
- Integrate Paragon Genomics’ CleanPlex NGS target enrichment technologies into Sophia AI platform
|
OpGen |
Qiagen |
- Objective: Offer Qiagen nucleic acid purification technology with OpGen’s Acuitas antimicrobial resistance detection panel
- Dynamic: OpGen to purchase Qiagen’s EZ1 Advanced XL automated nucleic acid purification instruments and reagent kits and offer them for use with its research-use-only Acuitas AMR Gene Panel u5.47 for detecting multidrug-resistant bacterial pathogens in urine or bacterial isolates
|
Thermo Fisher |
Symphogen |
- Objective: Develop validated platform workflows to monitor quality of complex therapeutic proteins
- Dynamic: Under 2-year agreement, Symphogen to use Thermo Scientific Q Exactive Plus Orbitrap liquid chromatography tandem mass spectrometry system with BioPharma Option to create platforms for analyzing therapeutic monoclonal antibody mixtures
|
NanoString |
MacroGenics |
- Objective: Develop biomarkers for MacroGenics’ MGD013 program
- Dynamic: Joint research using NanoString PanCancer IO 360 panel to identify potential signatures for MGD013
|
Precipio |
PerkinElmer |
- Jointly offer Precipio’s ICE COLD-PCR (ICP) mutation enrichment technology with PerkinElmer’s NextPrep-Mag cell-free DNA isolation kit, Janus G3 liquid handling workstation and Chemagic MSM I, Chemagic 360, and Chemagic Prime platforms
|
Leica Biosystems |
Ultivue |
- Objective: Comarket each company’s biomarker detection products
- Dynamic: Market Ultivue’s UltiMapper assays together with Leica’s Bond Rx research staining platform
|
Siemens Healthineers |
Healthy.io |
- Objective: Market smartphone system for home monitoring of chronic kidney disease
- Dynamic: Global original equipment manufacturer alliance integrating Siemens Healthineers urinalysis reagents into Healthy.io’s smartphone-based urinalysis system
|
23andMe |
MyoKardia |
- Objective: Advance hypertrophic cardiomyopathy (HCM) research
- Dynamic: Create patient community that 23andMe customers can use to access regularly updated HCM information
|
SeraCare Life Sciences |
AccuRef Diagnostics |
- Objective: Market AccuRef’s CRISPR-engineered cell line reference materials
- Dynamic: SeraCare to sell AccuRef materials in all markets but China
|
Invitae |
Alnylam Pharmaceuticals |
- Objective: Offer free genetic testing to improve diagnosis and management of primary hyperoxaluria
- Dynamic: Tests must be ordered by MDs with Invitae to provide test results in 2 weeks without giving Alnylam access to identifiable patient information
|
Berry Genomics |
Prenetics |
- Objective: Offer direct-to-consumer genetic testing services in Chinese market
- Dynamic: Create joint venture to sell integrated digital health and genetics testing services directly to consumers in mainland China
|
BGI |
Fred Hutchinson Cancer Research Center |
- Objective: Work together on cancer genomics, immunology and infectious disease projects
- Dynamic: Leverage BGI’s sequencing technology and Hutchinson’s cancer research and analysis expertise
|
BioLegend |
VIB |
- Objective: Deploy single-cell multi-omics technology
- Dynamic: Test and deploy BioLegend’s TotalSeq antibodies as part of workflow combing single-cell proteomics with single-cell transcriptomics
|
Oxford BioDynamics |
Casa Sollievo della Sofferenza |
- Objective: Identify blood-based biomarkers of autism spectrum disorder
- Dynamic: Develop autism biomarker assay based on Oxford BioDynamics’ EpiSwitch platform for discovery, evaluation, validation, and monitoring of chromosome conformation signatures
|
Almac Diagnostic Services |
TP Therapeutics |
- Objective: Develop NGS companion diagnostic for TP’s repotrectinib, an investigational tyrosine kinase inhibitor
- Dynamic: Almac to develop test based on tArcherDx Anchored Multiplex PCR chemistry and seek US regulatory approval
|
Quanterix |
OncoGenesis |
- Objective: Develop protein biomarker test for cervical disease
- Dynamic: Use Quanterix’s SP-X Imaging and Analysis system to create test
- OncoGenesis to handle commercialization of test
|
RTI |
Asuragen |
- Objective: Perform high-throughput screening testing for fragile X syndrome in newborns
- Dynamic: Screening to be conducted using Asuragen’s technology via North Carolina’s free Early Check study to identify children with rare health conditions before symptoms develop
|
Natera |
Neon Therapeutics |
- Use Natera’s Signatera circulating tumor DNA assay to assess treatment response to NEO-PV-01, a clinical trial-stage neoantigen cancer vaccine
|
OneOme |
Catherine Specialty Hospital |
- Offer OneOme’s PGx testing to patients of hospital (located in Croatia)
|
DISTRIBUTION, SALES & MARKETING AGREEMENTS |
Property Owner |
Distributor |
Deal Summary |
Syntec |
Bioké |
- Products: Syntec’s Medimachine semi-automated homogenizer products
- Territory: Netherlands, Belgium, Luxembourg
- Exclusive
|
Guardant Health AMEA |
Core Diagnostics |
- Products: Guardant’s Guardant360 comprehensive liquid biopsy test
- Territory: India
- Expansion of exclusive distribution deal from five to eight years following first Chinese regulatory approval
|
SpeeDx |
Axonlab |
- Products: ResistancePlus GC, ResistancePlus MG and other SpeeDx tests
- Territory: Germany, Belgium, Netherlands, Luxembourg, Switzerland
|
SpeeDx |
Vircell |
- Products: ResistancePlus GC, ResistancePlus MG and other SpeeDx tests
- Territory: Spain
|
SpeeDx |
Diamedica |
- Products: ResistancePlus GC, ResistancePlus MG and other SpeeDx tests
- Territory: Estonia, Latvia, Lithuania
|
SpeeDx |
Biomedica |
- Products: ResistancePlus GC, ResistancePlus MG and other SpeeDx tests
- Territory: Central Eastern Europe
|
Dovetail Genomics |
Premas Life Sciences |
- Products: Dovetail’s genomics products and services
- Territory: India
|
Dovetail Genomics |
Millennium Science |
- Products: Dovetail’s genomics products and services
- Territory: Australia and New Zealand
|
Dovetail Genomics |
Ultravision Technology + Shanghai Biozeron Biotechnology |
- Products: Dovetail’s genomics products and services
- Territory: China
|
Dovetail Genomics |
Genomics Bioscience |
- Products: Dovetail’s genomics products and services
- Territory: Taiwan
|
Dovetail Genomics |
Bio-Active |
- Products: Dovetail’s genomics products and services
- Territory: Thailand
|
Dovetail Genomics |
Biomedic Science Material |
- Products: Dovetail’s genomics products and services
- Territory: Vietnam
|
Karius |
Dasa |
- Products: Karius’s NGS-based infectious disease test
- Territory: Brazil
|
OncoDNA |
Gammaray Private Health Services |
- Products: OncoDNA’s molecular profiling tests
- Territory: Turkey
|
OncoDNA |
AMS 2000 Trading Impex |
- Products: OncoDNA’s molecular profiling tests
- Territory: Romania
|
LICENSES |
Licensor |
Licensee |
Deal Summary |
Expedeon |
Quanterix |
- Property: CaptSure immunoassay products + Lightning-Link antibody labeling tech
- Non-exclusive
|
ERS Genomics |
DefiniGen |
- Property: CRISPR-Cas9 genome editing tech
- DefiniGen to combine with its stem cell differentiation platform to generate preclinical cell models for type 2 diabetes, rare liver diseases and non-alcoholic fatty liver disease drug discovery
|
Broad Institute |
DefiniGen |
- Property: CRISPR-Cas9 genome editing tech
- For use in developing human cell disease models
|
Co-Diagnostics |
LGC Biosearch Technologies |
- Property: CoPrimer PCR technology
- Exclusive for research and commercial applications in agriculture
|
XCR Diagnostics |
Luminex |
- Property: XCR’s Xtreme Chain Reaction nucleic acid amplification technology
- Non-exclusive
|
National University of Singapore |
Proteona |
- Property: Sequencing-based protein analysis technology
- Global exclusive
|
SUPPLY, SERVICE & TESTING AGREEMENTS |
Supplier/Servicer |
Client/User |
Deal Summary |
LabCorp |
Horizon Blue Cross Blue Shield of New Jersey |
- Renewal of lab services agreement but LabCorp no longer exclusive provider
|
Quest |
Horizon Blue Cross Blue Shield of New Jersey |
- Addition of Quest as lab services provider, a status previously reserved exclusively to LabCorp
|
Clinical Genomics |
Quest |
- 5-year extension of US supply agreement for InSure One fecal immunochemical test (FIT)
|
Stratec Consumables |
Vortex BioSciences |
- Stratec to provide materials for use in creating microfluidic chip used in Vortex’s VTX-1 Liquid Biopsy System
|